This book is the culmination of three decades of accumulated experience in teaching biotechnology professionals. It distills the fundamental principles and essential knowledge of cell culture processes from across many different disciplines and presents them in a series of easy-to-follow, comprehensive chapters. Practicality, including technological advances and best practices, is emphasized.
This second edition consists of major updates to all relevant topics contained within this work. The previous edition has been successfully used in training courses on cell culture bioprocessing over the past seven years. The format of the book is well-suited to fast-paced learning, such as is found in the intensive short course, since the key take-home messages are prominently highlighted in panels. The book is also well-suited to act as a reference guide for experienced industrial practitioners of mammalian cell cultivation for the production of biologics.
Preface
Chapter 1 : Overview of Cell Culture Processes
Chapter 2 : Cell Biology for Bioprocessing
Chapter 3 : Cell Physiology
Chapter 4 : Product Quality and Process
Chapter 5 : Stoichiometry and the Kinetics of Cell Cultivation
Chapter 6 : Cell Line Development
Chapter 7 : Medium Design for Cell Culture Processing
Chapter 8 : Cell Culture Bioreactors
Chapter 9 : Fed-Batch Culture Processes
Chapter 10 : Continuous Cell Culture Processes
Chapter 11 : Oxygen Transfer in Cell Culture Bioreactors
Chapter 12 : Scaling Up and Scaling Down for Cell Culture Bioreactors
Appendix A : Cell Culture Process Data Analysis
Index
