This handbook defines the discipline of Biomedical Engineering by bringing together the core of knowledge that now makes up this rapidly growing field. The book is primarily written for the biomedical engineering professional who needs factual information on a particular topic or the professional from other engineering and medical disciplines who wants a comprehensive overview of the entire field. The second edition has been completely updated and revised.
VOLUME 1
Section I : Physiologic Systems
Chapter 1 : An Outline of Cardiovascular Structure and Function
Chapter 2 : Endocrine System
Chapter 3 : Nervous System
Chapter 4 : Vision System
Chapter 5 : Auditory System
Chapter 6 : The Gastrointestinal System
Chapter 7 : Respiratory System
Section II : Bioelectric Phenomena
Chapter 8 : Basic Electrophysiology
Chapter 9 : Volume Conductor Theory
Chapter 10 : The Electrical Conductivity of Tissues
Chapter 11 : Membrane Models
Chapter 12 : Numerical Methods for Bioelectric Field Problems
Chapter 13 : Principles of Electrocardiography
Chapter 14 : Principles of electromyography
Chapter 15 : Principles of Electroencephalography
Chapter 16 : Biomagnetism
Chapter 17 : Electric Stimulation of Excitable Tissue
Section III : Biomechanics
Chapter 18 : Mechanics of Hard Tissue
Chapter 19 : Mechanics of Blood Vessels
Chapter 20 : Joint-Articulating Surface Motion
Chapter 21 : Joint Lubrication
Chapter 22 : Musculoskeletal Soft Tissue Mechanics
Chapter 23 : Mechanics of Head/Neck
Chapter 24 : Biomechanics of Chest and Abdomen Impact
Chapter 25 : Analysis of Gait
Chapter 26 : Exercise Physiology
Chapter 27 : Factors Affecting Mechanics Work in Humans
Chapter 28 : Cardiac Biodynamics
Chapter 29 : Heart Valve Dynamics
Chapter 30 : Arterial Macrocirculatory Hemodynamics
Chapter 31 : Mechanics and Transport in The Microcirculation
Chapter 32 : Mechanics and Deformability of Hematocytes
Chapter 33 : The Venous System
Chapter 34 : Mechanics of Tissue/Lymphatic Transport
Chapter 35 : Cochlear Mechanics
Chapter 36 : Vestibular Mechanics
Section IV : Biomaterials
Chapter 37 : Metallic Biomaterials
Chapter 38 : Ceramic Biomaterials
Chapter 39 : Polymeric Biomaterials
Chapter 40 : Composite Biomaterials
Chapter 41 : Biodegradable Polymeric Biomaterials: An Updated Overview
Chapter 42 : Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen)
Chapter 43 : Soft Tissue Replacements
Chapter 44 : Hard Tissue Replacements
Chapter 45 : Preservation Techniques for Biomaterials
Chapter 46 : Hip Joint Prosthesis Fixation-Problems and Possible Solutions
Section V : Biomedical Sensors
Chapter 47 : Physical Measurements
Chapter 48 : Biopotential Electrodes
Chapter 49 : Electrochemical Sensors
Chapter 50 : Optical Sensors
Chapter 51 : Bioanalytic Sensors
Section VI : Biomedical Signal Analysis
Chapter 52 : Biomedical Signals: Origin and Dynamic Characteristics; Frequency-Domain Analysis
Chapter 53 : Digital Biomedical Signal Acquisition and Processing
Chapter 54 : Compression of Digital Biomedical Signals
Chapter 55 : Time-Frequency Signal Representations for Biomedical Signals
Chapter 56 : Wavelet (Time-Scale) Analysis in Biomedical Signal Processing
Chapter 57 : Higher-Order Spectral Analysis
Chapter 58 : Neural Networks in Biomedical Signal Processing
Chapter 59 : Complexity, Scaling and Fractals in Biomedical Signals
Chapter 60 : Future Directions: Biomedical Signal Processing and Networked Multimedia Communications
Chapter 61 : X-Ray
Chapter 62 : Computed Tomography
Chapter 63 : Magnetic Resonance Imaging
Chapter 64 : Nuclear Medicine
Chapter 65 : Ultrasound
Chapter 66 : Magnetic Resonance Microscopy
Chapter 67 : Positron-Emission Tomography (PET)
Chapter 68 : Electrical Impedance Tomography
Chapter 69 : Medical Applications of Virtual Reality Technology
Section VIII : Medical Instruments and Devices
Chapter 70 : Biopotential Amplifiers
Chapter 71 : Noninvasive Arterial Blood Pressure and Mechanics
Chapter 72 : Cardiac Output Measurement
Chapter 73 : Bioelectric Impedance Measurements
Chapter 74 : Respiration
Chapter 75 : Clinical Laboratory: Separation and Spectral Methods
Chapter 76 : Clinical Laboratory: Nonspectral Methods and Automation
Chapter 77 : Implantable Cardiac Pacemakers
Chapter 78 : Implantable Stimulators for Neuromuscular Control
Chapter 79 : External Defibrillators
Chapter 80 : Implantable Defibrillators
Chapter 81 : Electrosurgical Devices
Chapter 82 :Mechanics Ventilation
Chapter 83 : Parenteral Infusion Devices
Chapter 84 : Essentials of Anesthesia Delivery
Chapter 85 : Biomedical Lasers
Chapter 86 : Noninvasive Optical Monitoring
Chapter 87 : Medical Instruments and Devices Used in The Home
Chapter 88 : Virtual Instrumentation
Section IX : Biologic Effects of Nonionizing Electromagnetic Fields
Chapter 89 : Dielectric Properties of Tissues
Chapter 90 : Low-Frequency Magnetic Fields: Dosimetry, Cellular, and Animal Effects
Chapter 91 : Therapeutic Applications of Low-Frequency Sinusoidal and Pulsed Electric and Magnetic Fields
Chapter 92 : Biologic Effects of Radiofrequency and Microwave Fields: In Vivo and in Vitro Experimental Results
Chapter 93 : Radio Frequency Hyperthermia in Cancer Therapy
Chapter 94 : Electroporation of Cells and Tissues
Appendix A
Index
VOLUME 2
Section X : Transport Phenomena and Biomimetic Systems
Chapter 95 : Biomimetic Systems
Chapter 96 : Diffusional Processes and Engineering Design
Chapter 97 : Animal Surrogate Systems
Chapter 98 : Microvascular Heat Transfer
Chapter 99 : Interstitial Transport in The Brain: Principles for Local Drug Delivery
Chapter 100 : Arterial Wall Mass Transport: The Possible Role of Blood Phase Resistance in the Localization of Arterial Disease
Section XI : Biotechnology
Chapter 101 : Protein Engineering
Chapter 102 : Monoclonal Antibodies and Their Engineered Fragments
Chapter 103 : Antisense Technology
Chapter 104 : Tools for Genome Analysis
Chapter 105 : Vaccine Production
Chapter 106 : Gene Therapy
Chapter 107 : Cell Engineering
Chapter 108 : Metabolic Engineering
Section XII : Tissue Engineering
Chapter 109 : Tissue Engineering
Chapter 110 : Surface Immobilization of Adhesion Ligands for Investigations of Cell-Substrate Interactions
Chapter 111 : Biomaterials: protein-Surface Interactions
Chapter 112 : Engineering Biomaterials for Tissue Engineering: The 10-100 Micron Size Scale
Chapter 113 : Regeneration Templates
Chapter 114 : Fluid Shear Stress Effects on Cellular Function
Chapter 115 : The Roles of Mass Transfer in Tissue Function
Chapter 116 : The Biology of Stem Cells
Chapter 117 : Cell Motility and Tissue Architecture
Chapter 118 : Tissue Microenvironments
Chapter 119 : The Importance of Stromal Cells
Chapter 120 : Tissue Engineering of Bone Marrow
Chapter 121 : Tissue Engineering of The Liver
Chapter 122 : Tissue Engineering in The Nervous System
Chapter 123 : Tissue Engineering in The Skeletal Muscle
Chapter 124 : Tissue Engineering of Cartilage
Chapter 125 : Tissue Engineering of The Kidney
Section XIII : Prostheses and Artificial Organs
Chapter 126 : Artificial Heart and Circulatory Assist Devices
Chapter 127 : Cardiac Valve Prostheses
Chapter 128 : Vascular Grafts
Chapter 129 : Artificial Lungs and Blood-Gas Exchange Devices
Chapter 130 : Artificial Kidney
Chapter 131 : Peritoneal Dialysis Equipment
Chapter 132 : Therepeutic Apheresis and Blood Fractionation
Chapter 133 : Liver Support Systems
Chapter 134 : Artificial Pancreas
Chapter 135 : Nerve Guidance Channels
Chapter 136 : Tracheal, Laryngeal, and Esophageal Replacement Devices
Chapter 137 : Artificial Blood
Chapter 138 : Artificial Skin and Dermal Equivalents
Section XIV : Rehabiliation Engineering
Chapter 139 : Rehabilitation Engineering, Science, and Technology
Chapter 140 : Orthopedic Prosthetics and Orthotics in Rehabilitation
Chapter 141 : Wheeled Mobility: Wheelchairs and Personal Transportation
Chapter 142 : Externally Powered and Controlled Orthotics and Prosthetics
Chapter 143 : Sensory Augmentation and Substitution
Chapter 144 : Augmentative and Alternative Communication
Chapter 145 : Measurement Tools and Processes in Rehabilitation Engineering
Chapter 146 : Rehabilitation Engineering Technologies: Principles of Application
Section XV : Human Performance Engineering
Chapter 147 : A Working Model for Human System-Task Interfaces
Chapter 148 : Measurement of Neuromuscular Performance Capacities
Chapter 149 : Measurement of Sensory-Motor Control Performance Capacities: Tracking Tasks
Chapter 150 : Measurement of Information-Processing Performance Capacities
Chapter 151 : High-Level Task Analysis: Mental Components
Chapter 152 : Task Analtsis and Decomposition: Physical Components
Chapter 153 : Human-Computer Interface Design Issues
Chapter 154 : Applications of Human Performance Measurements to Clinical Trials to Determine Therapy Effectiveness and Safety
Chapter 155 : Applications of Quantitative Assessment of Human Performance in Occupational Medicine
Chapter 156 : Human Performance Engineering Computer-Based Design and Analysis Tools
Chapter 157 : Human Performance Engineering: Challenges and Prospects for The Future
Section XVI : Physiological Modeling, Simulation, and Control
Chapter 158 : Modeling Strategies in Physiology
Chapter 159 : Compartmental Models of Physiologic Systems
Chapter 160 : Cardiovascular Model and Control
Chapter 161 : Respiratory Models andControl
Chapter 162 : Neural Networks for Physiological Control
Chapter 163 : Methods and Tools for Identification of Physiologic Systems
Chapter 164 : Autoregulating Windkessel Dynamics May Cause Low Frequency
Chapter 165 : Control of Movements
Chapter 166 : The Fast Eye Movement Control System
Section XVII : Clinical Engineering
Chapter 167 : Clinical Engineering: Evolution of a Discipline
Chapter 168 : Management and Assessment of Medical Technology
Chapter 169 : Risk Factors, Safety, and Management of Medical Equipment
Chapter 170 : Clinical Engineering program Indicators
Chapter 171 : Quality of Improvement and Team Building
Chapter 172 : A Standards Primer for Clinical Engineers
Chapter 173 : Regulatory and Assessment Agencies
Chapter 174 : Applications of Virtual Instruments in Health Care
Section XVIII : Medical Informatics
Chapter 175 : Hospital Information Systems: Their Function and State
Chapter 176 : Computer-Based Patient Records
Chapter 177 : Computer Networks in Health Care
Chapter 178 : Overview of Standards Related to The Emerging Health Care Information Infrastructure
Chapter 179 : Non-AI Decision Making
Chapter 180 : Design Issues in Developing Clinical Decision Support and Monitoring Systems
Section XIX : Artificial Intelligence
Chapter 181 : Artificial Intelligence in Medical Decision Making: History, Evolution, and Prospects
Chapter 182 : Artificial Neural Networks: Definitions, Methods, Applications
Chapter 183 : Clinical Decision Systems
Chapter 184 : Expert Systems: Methods and Tools
Chapter 185 : Knowledge Acquisition and Representation
Chapter 186 : Knowledge-Based Systems for Intelligent Patient Monitoring and Management in Critical Care Environments
Chapter 187 : Medical Terminology and Diagnosis Using Knowledge Bases
Chapter 188 : Natural Language Processing in Biomedicine
Section XX : Ethical Issues Associated With The Use of Medical Technology
Chapter 189 : Professional Ethics in Biomedical Engineering
Chapter 190 : Beneficence, Nonmaleficence, and Technological Progress
Chapter 191 : Ethical Issues of Animal and Human Experimentation in The Development of Medical Devices
Chapter 192 : Regulation of Medical Device Innovation
Appendix A
Index
