Handbook for Chemical Process Research and Development, 2nd Edition

Title: Handbook for Chemical Process Research and Development, 2nd Edition
Author: Wenyi Zhao
ISBN: 1032259272 / 9781032259277
Format: Hard Cover
Pages: 866
Publisher: CRC Press
Year: 2023
Availability: 2 to 3 weeks

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This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies.

Features:

  • This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner.
  • Promotes an industrial mindset concerning safety and commercial viability when developing methods.
  • The author discusses development strategies with case studies and experimental procedures.
  • Focuses on mechanism-guided process development which provides readers with practical strategies and approaches.
  • Addresses more common process issues such as safety, cost, robustness, and environmental impact.

This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.

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Preface

Chapter 1 :
Reaction Solvent Selection
Chapter 2 : Reagent Selection
Chapter 3 : Various Reagent Surrogates
Chapter 4 : Modes of Reagent Addition -Control of Impurity Formation
Chapter 5 : Process Optimization with Additives
Chapter 6 : Process Optimization of Catalytic Reactions
Chapter 7 : Process Optimization of Problematic Reactions
Chapter 8 : Hazards of Oxidation and Reduction Reactions
Chapter 9 : Other Hazardous Reactions
Chapter 10 : Hazardous Reagents
Chapter 11 : Grignard Reagent and Related Reactions
Chapter 12 : Challenging Reaction Intermediates
Chapter 13 : Protecting Groups
Chapter 14 : Telescope Approach
Chapter 15 : Design of New Synthetic Route
Chapter 16 : Stereochemistry
Chapter 17 : Various Quenching Strategies
Chapter 18 : Various Isolation and Purification Strategies
Chapter 19 : Methods for Residual Metal Removal
Chapter 20 : Methods for Impurity Removal
Chapter 21 : Pharmaceutical Salts
Chapter 22 : Solid Form

Index